Part:BBa_K3117039

kappa light chain

Usage and Biology

Part BBa_K3117039 is the constant part of the light chain within an antibody. Together with the single chain variable fragment, the kappa-light chain forms the variable light chain of an antibody. Additionally, the kappa-light chain binds to the constant region 1 (BBa_K3117040) of an antibody via disulfid bonds.

MIT_MAHE 2020

Summary

Kappa light chain is the constant part of the light chain within an antibody. Together with the single chain variable fragment, the kappa-light chain forms the variable light chain of an antibody. Additionally, the kappa-light chain binds to the constant region 1 of an antibody via disulfide bonds.

References

1. Vincent Rajkumar S. (2014). Multiple myeloma: 2014 Update on diagnosis, risk-stratification, and management. American journal of hematology, 89(10), 999–1009. https://doi.org/10.1002/ajh.23810

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3. Chen, J., Fang, M., Zhao, Y. P., Yi, C. H., Ji, J., Cheng, C., Wang, M. M., Gu, X., Sun, Q. S., Chen, X. L., & Gao, C. F. (2015). Serum N-Glycans: A New Diagnostic Biomarker for Light Chain Multiple Myeloma. PloS one, 10(6), e0127022. https://doi.org/10.1371/journal.pone.0127022

4. Siegel, R., Ma, J., Zou, Z., & Jemal, A. (2014). Cancer statistics, 2014. CA: a cancer journal for clinicians, 64(1), 9–29. https://doi.org/10.3322/caac.21208 "